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Hubungan antara Stres Oksidatif dengan Kadar Hemoglobin pada Penderita Thalassemia /Hbe (Correlation between Stres Oxidatif and Hemoglobine Level of Thalassemia /Hbe)

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Chronic transfusion on thalassemia patients may cause excess of body iron. The increase of body iron may stimulate oxidant production such as reactive oxygen species (ROS) that measured as malondialdehyde (MDA). Increase of ROS production cause cell including erythrocyte membrane destruction that contained lipid compound. The purpose of this research iso determine the corelation between serum level of MDA and hemoglobine level of thalassemia/HbE patients. An observational cohort prospective study has been conducted on Blood Transfusion Unit of Semarang City. On the period of January 2006 until December 2009 about 32 patients thalassemia /HbE were recruited.
Research variables were hemoglobine level and MDA serum. Measurement were conducted before transfusion I, after transfusion II and before transfusion II. Statistical analysis by using Mann-whitney. Wilcoxon test and Spearman-Rank correlation. Average of age was 9,5±3,13 year, sex was 25 boys (46,9%) and 17 girls (53,1%). About 43,8% was have poor nutritional status. MDA level on Hb before transfusion /I 8 g/dL group was 2,89±0,451 and Hb >8 g/dL group was 2,19±0,792 (p=0,01). There were negative correlation between Hb before transfusion /I with MDA (r=min 0,52; p=0,002). MDA serum was negatively correlated with hemoglobin level of thalassemia /HbE patients.
Keywords: Hemoglobin, MDA, oxidative stress, thalassemia /HbE

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No. Panggil

Jurnal Kedokteran Brawijaya, 27 (1) 2012 : 38-42

Penerbit

Malang : FK Universitas Brawijaya., 2012

Deskripsi Fisik

5p

Bahasa

ISBN/ISSN

0216-9347

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