Text

Hubungan Kadar TGF-β 1 dan IFN-γ dengan Indeks Kronisitas Nefritis Lupus (Relationship TGF-81 and IFN-γ Levels with Lupus Nephritis Chronicity Index)

---

Although improvements have been made in the therapeutic management of the last two decades, but the prognosis of lupus nephritis remains unsatisfactory. It is therefore necessary to idenitfy a biomarker of disease activity. This study was aimed to measure the role ofTGF-61 and IFN-γ urine as biomarker for chronicity index of lupus nephritis. An observational study was conducted over al-year using urine samples from 25 study subjects to measure correlation between levels of TGF-β1 and IFN-γ levels measured by using ELlSA method and the histopathological chronicity index of lupus nephritis. The data were analyzed using unpaired t test and Pearson correlation. The result show a significant differences between the mean of the cases (Iupus nephritis) (i97,87±96,74) and the control group (non lupus nephritis) (17,82±18) on the measurement levels of IFN-γ urine, while no significant difference (p=0425>a) in TGF-β1 between the case group (34,51±11,17) and the control group (30,27±5,87). A positive and strong correlation were identified between levels of IFN-γurine and urinary TGF-61 (p=0,000, r

---

Availability

Detail Information

Series Title

-

Call Number

Jurnal Kedokteran Brawijaya, 27 (1) 2012 : 16-20

Publisher

Malang : FK Universitas Brawijaya., 2012

Collation

5p

Language

ISBN/ISSN

0216-9347

Classification

-

Content Type

-

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

-

Specific Detail Info

-

Statement of Responsibility

-

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment