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Hubungan Kadar TGF-β 1 dan IFN-γ dengan Indeks Kronisitas Nefritis Lupus (Relationship TGF-81 and IFN-γ Levels with Lupus Nephritis Chronicity Index)

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Although improvements have been made in the therapeutic management of the last two decades, but the prognosis of lupus nephritis remains unsatisfactory. It is therefore necessary to idenitfy a biomarker of disease activity. This study was aimed to measure the role ofTGF-61 and IFN-γ urine as biomarker for chronicity index of lupus nephritis. An observational study was conducted over al-year using urine samples from 25 study subjects to measure correlation between levels of TGF-β1 and IFN-γ levels measured by using ELlSA method and the histopathological chronicity index of lupus nephritis. The data were analyzed using unpaired t test and Pearson correlation. The result show a significant differences between the mean of the cases (Iupus nephritis) (i97,87±96,74) and the control group (non lupus nephritis) (17,82±18) on the measurement levels of IFN-γ urine, while no significant difference (p=0425>a) in TGF-β1 between the case group (34,51±11,17) and the control group (30,27±5,87). A positive and strong correlation were identified between levels of IFN-γurine and urinary TGF-61 (p=0,000, r

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Jurnal Kedokteran Brawijaya, 27 (1) 2012 : 16-20

Penerbit

Malang : FK Universitas Brawijaya., 2012

Deskripsi Fisik

5p

Bahasa

ISBN/ISSN

0216-9347

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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