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Mekanisme Kerja Benalu Teh pada Pembuluh Darah (Mechanism of Tea Mistletoe Action on Blood Vessels)

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There are two types of hypertension treatment that are pharmacologic and non pharmacologic treatments. Non pharmacologic treatments such as herbal teas using the mistletoe from the family Loranthaceae (Viscum album, Dendrophtoe pentandra (L) Miq, Scurrula parasitica, Scurulla oortiana, and Macrosolen javanus) is potential as anti hypertension (vasodilator). The mechanism of tea mistletoe action in the blood vessels occur in smooth muscIe and endothelial target organ. Flavonoids of tea mistletoe, in this case quersetin, is able to work directly on the smooth muscIe of blood vessett: to stimulate or activate Endothelium Derived Relaxing Factor, causing vasodilatation. Flavonoids such as polyphenols can increase the activity of Nitric Oxide Synthase (NOS) in vascular endothelial cells. Active substances can be diffused directly and synthesize Nitric Oxide (NO) in smooth muscIe and endothelial [urther stimulate guanyiate cyclase to form cGMP cause vasodilation. Mistletoe of tea as competitive a, receptor antagonism. Mistletoe of tea inhibit the Ca2+ channel 50 intracellular Ca2+. Thus, putative putative activity of mistletoe as competitive alpha 1 receptor antagonism does not increase and MLC become dephosphoriiation. The possibility of the mechanism of tea mistletoe inhibit flavonoid antioxidants can stimulate the production of NO that causes relaxation of blood vessels. Mistletoe of tea can inhibit the contraction of the orteries, through role of the endothelium. Clinically, endothelial progenitor cells can improve the condition of disease that begins with endothelial cell damage, such as hypertension. The mistletoe of tea flavonoids has a potential effect to improve endothelial dysfunction through a reendothelial mechanism.
Keywords: Endothelial cells, mistletoe, nitric oxide, smooth muscle, vasodilator

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Jurnal Kedokteran Brawijaya, 27 (1) 2012 : 1-7

Penerbit

Malang : FK Universitas Brawijaya., 2012

Deskripsi Fisik

7p

Bahasa

ISBN/ISSN

0216-9347

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