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Kadar Protein S-100 Serum Penderita Fraktur Oromaksilofasial yang Disertai Cedera Kepala Ringan (Serum Levels of S-100 Protein in Oromaxillofacial Fracture Patients with Mild Head Injury)/

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Oromaxillofacial fracture is often accompanied by head injury due to its adjacent location and structure. Risk estimation for clinically relevant intracranial lesions after minor head injury remains a major diagnostic challenge. One possible method to evaluate the possibility of intracranial lesion is by using biomarkers (biochemical marker) protein S-100. Protein S-100 is a neuron-specific protein. The aim of present study was to assess the elevated levels of S-100 protein serum and to investigate whether there was any difference in the S-100 protein serum concentrations depending on the location of the oromaxillofacial fractures in mild head injury. This study was performed using analytic observational method with case control research design conducted at Dr. Hasan Sadikin General Hospital Bandung between November 2010 and January 2011. There were 76 samples, comprised of 38 adult patients with oromaxillofacial and mild head injury and 38 healthy adults as a control group.
The result showed that there was an increase level of S-100 protein serum concentrations in patients having oral and maxillofacial fractures with mild head injury. The concentration increased on average twice as much, which was statistically significant at t test=2.26 with p-value=0.0135. If one group of patients was compared with other patient groups, however, the results were not statistically significant, or it can be stated to have the same level of S-100 protein serum concentrations. In conclusion, oral and maxillofacial fractures in adult patients with mild head injury have elevated levels of S-100 protein serum concentrations and there is no difference in S-100 protein serum concentrations based on the location of oromaxillofacial fractures in mild head injury.
Key words: Mild head injury, oromaxillofacial fracture, S-100 protein serum

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Series Title

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Call Number

MKB: Majalah Kedokteran Bandung, 44 (4) 2012 : 233

Publisher

Bandung : FK UNPAD., 2012

Collation

7p

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ISBN/ISSN

0126-074x

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Edition

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Subject(s)

CRANIOCEREBRAL TRAUMA

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