Polimorfisme Gly972Arg Gen IRS-1 dan Cys981Tyr Gen PTPN1 sebagai Faktor Risiko pada Sindrom Metabolik dengan Riwayat Berat Bayi Lahir Rendah (Role of Polymorphism Gly972Arg Gene IRS-1 and Cys981Tyr Gene PTPN1 as Risk Factors in Metabolic Syndrome with History of Low Birth Weight) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Polimorfisme Gly972Arg Gen IRS-1 dan Cys981Tyr Gen PTPN1 sebagai Faktor Risiko pada Sindrom Metabolik dengan Riwayat Berat Bayi Lahir Rendah (Role of Polymorphism Gly972Arg Gene IRS-1 and Cys981Tyr Gene PTPN1 as Risk Factors in Metabolic Syndrome with History of Low Birth Weight)

Hikmat Permana - Personal Name; gaga Irawan Nugraha - Personal Name; Sri Hartini K. S. Kariadi - Personal Name;

Increasing prevalence of obesity occurs worldwide and can affect all ages levels. Risk factors of increasing metabolic syndrome were associated with changes in lifestyle, obesity and low birth weight (LBW). This study was aimed to analyze the genotype IRS-1, genotype PTPN1 and LBW in metabolic syndrome risk factors. In 2009, this restrospective cohort study was comprised of 97 LBW and 100 normal birth weight (NBW), aged 20–21 years old, from the previous cohort study in District Tanjung Sari since 1989. The role of IRS-1 gene, PTPN1 gene and LBW in the metabolic syndrome factors were analyzed using multiple logistic regressions. The result showed there were no significant relationship between IRS-1 and PTPN1 genotype with metabolic syndrome factors but only IRS-1 genotype was significantly associated with trygliceride (p=0.006). Gly972Arg IRS-1 gene polymorphism in LBW has predictive value of increasing diastolic blood pressure, waist circumference and trygliceride. Cys981 Tyr PTPN1 gene polymorphism showed a risk factor for systolic blood pressure and high density lipoprotein (HDL) cholesterol. Gly972Arg IRS-1 gene polymorphism was a dominant factor to increase diastolic blood pressure, waist circumference and trygliceride. In conclusions, Cys981 Tyr PTPN1 gene polymorphism is a risk factor of increased systolic blood pressure and HDL cholesterol, and LBW is the risk factor increasing fasting glucose level.

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Location name is not set MKB: Majalah Kedokteran Bandung, 44 (3) 2012 : 170

A0003032

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Series Title: -
Call Number: MKB: Majalah Kedokteran Bandung, 44 (3) 2012 : 170
Publisher: Bandung : FK UNPAD., 2012
Collation: 9p
Language
ISBN/ISSN: 0126-074x
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): infant, low birth weight
RISK FACTORS
POLYMORPHISM, GENERIC
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