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Antioksidan Ekstrak Air Biji Kopi Robusta Lampung dalam Menghambat Degenerasi Sel Hati Tikus Model Hepatitis yang Diinduksi CCL4 (Antioxidant of Lampung RobustaCoffee Beans Water Extract in Inhibiting Liver Cell Degeneration in CCl4 Induced Hepatitis Rats Model)

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Liver plays an important role in maintaining homeostasis and is critical for physiological functions of other organs. Morphological changes of the liver will have an impact on changes in liver function and may appear as clinical manifestations. Hepatitis is a serious disorder that causes inflammation of the liver cells and is caused by viruses, chemicals and toxins. Reactions that occur in the form of oxidative stress, free radicals dominant condition of antioxidants. Traditionally coffee is used as an everyday beverage and known as antioxidants because it contains flavonoids (chlorogenic acid). This study aim was to determine the hepatoprotective/antioxidant effect of coffee growing in Pesawaran Lampung, on the description of hepatocyte cell damage in Wistar rats hepatitis model induced with carbon tetrachloride (CCl4). Laboratory experimental research has been conducted in Pharmacology >Department, Faculty Medicine Padjadjaran University Bandung and pathology examinations was performed at the Hospital Abdoel Moeloek Lampung in December 2008–July 2009, using 15 male Wistar rats divided in three groups, the negative control group, positive control as a model of hepatitis, and hepatitis model that received the water extract of robusta coffee beans 25 mg/kgBW/days for 7 days and then received CCl4 induction. The results were analyzed by analysis of variance and independent t test. Administration of water extract of robusta coffee beans can prevented damage to the liver cell degeneration picture from 58.4±7.09 to 34.4±5.85, these results differed significantly (p≤0.05) compared with positive and negative control. In conclusion, water extract of robusta coffee beans has the potential to prevent interference with the effects of liver function as antioxidants in the ra model of hepatitis which has been inducted with CCL4

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Series Title

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Call Number

MKB: Majalah Kedokteran Bandung, 44 (3) 2012 : 127

Publisher

Bandung : FK UNPAD., 2012

Collation

6p

Language

English

ISBN/ISSN

0126-074x

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Edition

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Subject(s)

antioxidants
hepatitis
COFFEE
HEPATOCYTES

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