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Nilai Indeks Terapi Ekstrak Etanol Daun Dewa {Gynura pseudochina (Lour.) DC} dan Natrium Diklofenak pada Tikus Model Inflamasi Therapeutic Index of Dewa Leaf {Gynura pseudochina (Lour.) DC} Ethanol Extract and Sodium Diclofenac in Inflammation Rat Model

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Therapeutic index, a drug safety parameter, is comparation between the dose at which 50% animals are dead (LD50) and the dose at which 50% animals exhibit the specified effect (ED50). Inflammation was a basic process in various diseases and Dewa leaf {Gynura pseudochina (Lour.) DC} was one of the herbal plants which has been proved as an anti-inflammatory. This study was conducted in order to know therapeutic index of Dewa leaf ethanol extract and sodium diclofenac, a common use non steroid anti inflammation drug (NSAID). The study was conducted in the Laboratory of Clinical Pharmacology Dr. Hasan Sadikin Hospital Faculty of Medicine Padjadjaran University in August–October 2009. This study used laboratory experimental design with a complete randomized block. Median effective dose was counted based on the ability to inhibit the inflammation process until maximal 75% in fifth hour after treatment. Median lethal dose was counted based on number animals dead until 14 days after single dose with oral administration. This research showed that ED50 of Dewa leaf ethanol extract (22.78 mg/kgBW) was bigger than ED50 of sodium diclofenac (1.13 mg/kgBW) and LD50 of Dewa leaf ethanol extract (28,352.84 mg/kgBW) was bigger than LD50 of sodium diclofenac (49.41 mg/kgBW). Therapeutic index of Dewa leaf ethanol extract (1,245:1) as anti-inflammatory was bigger than therapeutic index of sodium diclofenac (44:1). In conclusion, for a safetyness Dewa leaf ethanol extract is better than sodium diclofenac in inflammationrat model. [MKB. 2012;44(2):90–5].
Key words: Anti-inflammatory, dewa leaf, ED50, LD50, sodium diclofenac, therapeutic index

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MKB Majalah Kedokteran Bandung, 44 (2) 2012 : 90-9

Publisher

Bandung : FK UNPAD., 2012

Collation

6p

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ISBN/ISSN

0126-074x

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Subject(s)

plants, medicinal
inflammation
ALCOHOLIC BEVERAGES

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