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Efek hepatoprotektif Rosella (Hibiscus sabdariffa L.) pada tikus Model Hepatitis (The Hepatoprotective Effect of Rosella (Hibiscus sabdariffa L.) on Hepatitis Model Rats)

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Hepatitis is initiated by pollutant which caused oxidative stress. Rosella (Hibiscus sabdariffa L.) contain flavonoid, an antioxidant which has been used traditionally in treating liver disease. The study aims to define the hepatoprotective effects of fresh rosella calyx ethanol extract (FRCEE) on hepatitis model rats with liver malondialdehyde (MDA) and serum glutamic piruvic transaminase (SGPT) level and hepatocyte morphology damage compared to vitamin E’s effects. The laboratory experimental study has been conducted on August 2009 at Department Pharmacology and Therapy Faculty of Medicine Padjadjaran University/Dr. Hasan Sadikin Hospital in 25 male Wistar rats, divided into 5 groups. Group 1 was negative control, group 2 was positive control (carbon tetrachloride/CCl4-hepatitis model rats), group 3 and 4 were hepatitis model rats that subsequently given 125 mg/kgBW of FRCEE (group 3) and 2.7 IU of vitamin E (group 4) for 8 days; group 5 was given FRCEE. Observations were done 48 hours after CCL4 induction. The results were analyzed by analysis of varian (ANOVA) and Tukey. The result showed that FRCEE inhibited increasing of liver MDA and SGPT level significantly different compared to positive control (MDA p=0.00, SGPT p=0.041) but not significantly different to group 4 (MDA p=1.00, SGPT p=0.192). Histological features showed macrovesicular on group 3, microvesicular vacuole on group 2; whereas vitamin E inhibited morphological damage. In conclusion, FRCEE has hepatoprotective effect on hepatitis model rats as antioxidant, but not superior compared to vitamin E. [MKB. 2012;44(2):83–9].
Key words: Hepatocyte, MDA, rosella, SGPT

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Bandung : FK UNPAD., 2012

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7p

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0126-074x

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Subject(s)

plants, medicinal
hepatitis

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