Genotype distribution of T cell receptor β gene in Indonesian nasopharyngeal carcinoma patients | Perpustakaan dan Galeri Kebijakan Kesehatan

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Genotype distribution of T cell receptor β gene in Indonesian nasopharyngeal carcinoma patients

Yurnadi Yurnadi - Nama Orang; R. Susworo - Nama Orang; Purnomo Soeharso - Nama Orang; Dwi A. Suryandari - Nama Orang; Nukman Moeloek - Nama Orang;

Background: Nasopharyngeal carcinoma (NPC) is a multifactorial genetic disease, characteristically endemic and shows considerable differences in its geographical distribution. Besides infection with EBV, genetic factors such as polymorphisms of TCR-β gene contribute to the incidence of NPC. This study investigates the association of TCR-β gene polymorphisms with individual susceptibility to develop NPC in Indonesian ethnic groups.

Methods: The study was carried out by the PCR-RFLP method using Bgl II restriction enzyme to digest TCR-β gene. The PCR-RFLP analysis of TCR-β gene was used to determine allotypes of TCR-β gene in NPC patients and control among ethnic Chinese and indigenous groups in the population of Indonesia.

Results: The results indicate that the distribution of TCR-β gene allotypes between NPC patients and controls are not significantly different (p > 0.05); however, the frequency of A allele tends to increase in NPC patients. The distribution of TCR-β gene allotypes between Chinese ethnic group was not signifi cantly different from indigenous groups (p > 0.05).

Conclusion: The distribution of TCR-β gene allele between NPC group and control groups showed no difference. The distribution of TCR-β gene between ethnic Chinese and indigenous groups showed no difference. Polymorphisms of TCR-β gene are not associated with NPC and ethnic groups in Indonesian population.

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Belum memasukkan lokasi medical journal of indonesia 20 (3) 2011 : 171-177

A0002950

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Informasi Detail

Judul Seri: -
No. Panggil: medical journal of indonesia, 20 (3) 2011 : 171-17
Penerbit: Jakarta : faculty of medicine, universitas indonesia., 2011
Deskripsi Fisik: 7p
Bahasa
ISBN/ISSN: 0853-1773
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: nasopharyngeal neoplasms
GENOTYPE
PATIENTS
RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA
Info Detail Spesifik: -
Pernyataan Tanggungjawab: -

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