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Analisis Interaksi NADH-ubiquinon oxidoreductase (complex I) dengan Kelompok Acetogenins pada Annona muricta

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Acetogenins contained in annona muricata have potential as inhibitors of the enzyme NADH-ubiquinon oxidoreductase (complex I). in cancer, inhibiten of the enzyme NADH-ubiquinon oxidoreductase (complex I) can reduce the production of ATP as an energy source of cancer cells. this in silico molecular docking method was used, to study the interaction between the enzyme as a receptor and ligand with a group of acetogeneins as rotenon and piericidin A as a standard compound. the interaction energy of binding, affinity bindiing and hydrogen bonding on ligand enzyme complexes was studied. the results showed that there were four acetogenins compounds that have a binding energy, binding affinity and interaction better than the standard compound. thus, it can be concluded that the four compounds can be used as anticancer.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

FARMASAINS 1 (4) 2011 :173-179

Penerbit

Jakarta : Fakultas Metematika dan Ilmu Pengetahuan Universitas Muhammadiyah Prof Dr. Hamka., 2011

Deskripsi Fisik

7p

Bahasa

English

ISBN/ISSN

2086-6968

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

NADH,NADPH OXIDOREDUCASES
ANNONA

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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