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Endothelin-1, Nitric Oxide, and Ratio of ET-1/NO in Erectile Dysfunction

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Objective: The aim of this study was to observe the level of Endothelin-1 (ET-1), Nitric oxide (NO), and the ratio of ET-1/NO in Erectile dysfunction (ED) and normal subjects.

Material & method: This case-control study was carried out in Makassar with subjects recruited from outpatient clinic at Wahidin Sudirohusodo Hospital and divided into 2 groups (56 subjects DE and 34 subjects normal). ET-1 and NO plasma were measured by ELISA technique according to protocol.

Results: The data showed that mean value of ET-1 in erectile dysfunction subjects was significantly higher (p < 0,05), while NO was significantly lower (p < 0,05) in DE groups compared to normal groups. The ratio of ET-1/NO was also significantly different between both groups.

Conclusion: We concluded that level of plasma ET-1, plasma NO, and the ET-1/NO ratio are important factors involved in ED pathomechanism.

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Detail Information

Series Title

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Call Number

Indonesian Journal Of Urology, 18 (2) 2011 : 44-47

Publisher

Surabaya : Ikatan Ahli Urologi Indonesia., 2011

Collation

4p

Language

ISBN/ISSN

0853-4438

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

impotence
NITRIC OXIDE
ENDOTHELIN-1

Specific Detail Info

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