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Evaluasi Penggunaan Artemisinin (ACT) pada Penderita Malaria Di Puskesmas Sioban Kecamatan Sipora Selatan Kabupaten Kepulauan Mentawai {Evaluation of Artemisinin (ACT) Therapy for Malaria at Sioban Health Center, South Sipora District in Mentawai Islands}

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Malaria is a public health problem in Indonesia. One of the problems encountered in the elimination of malaria is the resistance of Plasmodium against antimalaria drugs. Artemisinin (ACT) is aclass of antimalarial drugs that are schizonticide sesquiterpenes lactone blood for Plasmodium falciparumand P. vivax. ACT is a drug of choice for treatment in the malaria elimination program, due to the wide resistance of chloroquine and othe drugs. In severe and malaria with complications, intervenous (I.V.) injections of ACT was recommended. The objective of the research was to evaluate the appropriate ACTdose and indication, to evaluate the clinical and parasitological response and to monitor adverse event during ACT treatment in malaria patients in Sioban PHC. The research was conducted by using descriptive study, collecting data prospectively from malaria patients in Sioban PHC Sub District South Sipora Islands District Mentawai, from January-Desember 2009. The evaluation of the drug responses were collected from medical records, and laboratory examinations. During this research, the monitoring of side effects, clinical observations before and after medication were also conducted. The data of side effects collected from observation then were evaluated for the genesis of side effect by using Naranjo algorithm to define the level of possible (score 1-4), probable (score 5-8) and definite (score 9). A total of 33 patients (94.28 %) were not suffer from severe complication of malaria, therefore ACT injections were necessary for these cases. Another 2 patients (6%) suffered from severe malaria and needded ACT injection. Based on the clinical response, 31 patients (89%) were declared recovered from malaria, and 4 patients (11%) were declared not yet recovered from malaria. Based on parasitological response, the number of parasite in 34 patients (97,13%) reported to be 0 on D7, existence of parasites reported on 1 patients (2,86%). 32 patients (91,42%) suffered from ACT side effect and another 3 patients (8,57%) did not suffer the ACT side effect.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Jurnal Ekologi Kesehatan 10 (2) 2011 : 114-120

Penerbit

Jakarta : Puslitbang Ekologi dan Status Kesehatan., 2011

Deskripsi Fisik

7p

Bahasa

ISBN/ISSN

1412-4025

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

malaria
parasitic diseases
ARTEMISININS

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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