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Formulasi Tablet Lepas Lambat Dipiridamol dengan Sistem Mengapung

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Formulation of Dipyridamole Sustained Relese Tablet Using Floating System. Dipyridamole is a drug for prevention of postoperative thromboembolic of heart valve replacement and long term therapy of angina pectories will he well absorhed in stomach. To maintain therapeutic plasma concentration in long time and to increase biovalability is needed a sustained release dosage form having the long residence time in the shomach. The objective of this research was to make floating sustaimed release tablet of dipyridamole conforming to the requirement that was set up by dipyridamol therapeutic concentration. Tables were made by wet granlation method using aquadest as a liquid binder, HPMC K4M, Ac-di-sol. Aviced HPMC K4M, Ac-di-sol, Avicel PH 102, talk, and Mg stearat. Dioslution assay was control out using type 2 release tester at rotation speed of 50 rpm in medium 900 ml. HCI 0.1 N at 37 ± 0.5⁰C for 8 hours. The formulation containing at 50 mg dipitydamole, HPMC K4M (30%), Ac-di-sol (20%). Avicel PH 102 (37%), talk (2%), and Mg stearat (1%) released 59.61±6.73% and 89.34±5.87% of dipyridamole respectively after 4 and 8 hours that conformed to the requirement

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Makara,15(1)2011:15-20

Penerbit

Depok : Direktorat Riser dan Pengabdian Masyarakat U.I., 2011

Deskripsi Fisik

5p.

Bahasa

ISBN/ISSN

1693-6728

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

DIPYRIDAMOLE

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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