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Inhibition of Bile Acid Accumulation Decreased the excessive Hepatocyte Apoptosis and Improved the liver Secretion Functions on Obstructive Jaundice Patients

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Exessive hepatocyte apoptosis induced by bile acid accumulation occured in severe obstructive jaundice, and impair the liver secretion function. The objective of this study is to determine whether the inhibition of bile acid accumulation through bile duct decompression affect the excessive hepatocyte apoptosis and caused improvement the liver secretion function on human model. In this study we use a before and after study on severe obstructive jaundice patients due to extra hepatic bile duct tumor was decompressed. Bile duct decompressed. Bile duc decompression was performed as a model of the role of inhibition of bile acid accumulation inhibition bile acid accumulation and excessive hepatocyte apoptosis. Bile acid and marker of liver secretion functions were serially measured. Liver biopsy pre and post decompression was performed for Hepatocyte apoptosis pathologic examination by TUNEL florescing, which measured by 2 people in double blinded system. Total bile acid, and liver functions were measured by automated chemistry analyzer. The result of this study shows that twenty one obstructive jaundice patientswere included. After decompression the hepatocyte apoptosis index decreased from an average of 53.1 (SD 105) to 11.7 (SD 13.6)(p

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Detail Information

Series Title

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Call Number

Makara; 15(1)2011:1-5

Publisher

Depok : Direktorat Riser dan Pengabdian Masyarakat U.I., 2011

Collation

5p.

Language

English

ISBN/ISSN

1693-6728

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

liver
APOPTOSIS
HEPATOCYTES
BILE
JAUNDICE , OBSTRUCTIVE

Specific Detail Info

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