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Polymorphisms of Organic Cation Transporter 1 and the Drugs Response

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Polymorphisms of proteins which have an important role in drug transport, metabolism, and disposition in the body could affect the drugs afficacy and toxicity. The organic cation transporter 1 (OCT1), encoded by SLC22A1 gene, has been known as one of the polyspectic protein transporters which could effect some of the cationic drug respone such as metformin, levodopa and imatinib. However, the findings of many studies an association of OCTI polymorphisms and drug response both in Caucasian and Asian were still inconsistent. Moreover, this study’s topic in Asians was still uncommon. This review was aimed to explore the polymorphisms of OCT in Asians and Caucasians and to find the challenges of the next studies in Asians. The articles about DCTI polymorpisms were searched in the OubMed with the keywords: OCTI or. SI c22A1, polmorphisms. There were ten articles of OCTI polymorphisms which are related to the drug response and most of the studies were performed in Caucasian subjects. In Caucasians, the rs622342 varian might associated with the response of metformin and levodopa. Moreover, the R61c and420del varians still showed the inconsistent findings associated with metformin response. The non symonymous varians which were found in Caucasians were not found in Asian. However, the new non synonymous variants were found Japaneso, Chinese, Indian and Korea population and some of them were associated with the merfomin respone. The recent findings found in Caucasians cancer patients, were reletd to the association of non synonymous variants haplotype and the 5 Hydroxytriptamine Receptor Antagonists drug response. The inconsistent results of OCTI polymorphisms studies could the releted to the study’s sample size and design of the studies. Further studies which exploring the association of OCTI polymorphisms and drug pharmacokinetic profiles and/or drug respons, which were adjusted by genetic variants of proteins involved in drug transport, metabolism and disposition are still needed in both Caucasians and Asians. Additional large studies also considering non-genetic risk factors are werranted to implement the results of the various studies into clinical practice.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Journal of the Medical Sciences:43(2)2011:138-144

Penerbit

Yogyakarta : Faculty of Medicine Gajah Mada University., 2011

Deskripsi Fisik

6p.

Bahasa

English

ISBN/ISSN

0126-1312

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

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Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

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