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A Deterministic and stochastic Approach to Analyze Carbon Tetrachloride-Induced Liver Injury in rats

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A new spectrometrical methodwas developmend to determine a marker for liver damage. The aims of this study was to investiagte the pattern of cellular interaction in EDTA blood spectrometrically in rats that induced by carbon tetrachloride (CC14), Eight of white male rats (Rattus norvegicus L), aged of 2 months with body weight of 160-210g were divided into two groups with 4 rats in each group. The first group as control were not fed and the second group as treatment were fed with 0.1 mL/kgBW CCI4 for 21 weeks. At the end of the experiment were fasfed ovemight, 3.0 mL of blood was drawn from the vena orbitalis for spectrometrical and biochemical estimation. Rats were then sacrificed and the liver tissue was used for histological assessment. All data were analyzed with t test.Histopathological studies of treated group showed the damage of the liver cells compared with control group. The results showed no significant difference in ALT (p=0.12) and AST (p=0.19) but significant difference in AST/ALT ratio (p=0.01) between 2 groups was observed. The deterministic and stochastic approaches showed no significant differences in k7 (p=0.11) but significant difference in k6 (p=0.00) and k8(p=0.00). It was concluded that the combination of deterministic approaches can be used to determine a maker for liver damage.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Journal of the Medical Sciences:42(2)2011:79-86

Penerbit

Yogyakarta : Faculty of Medicine Gajah Mada University., 2011

Deskripsi Fisik

7p.

Bahasa

English

ISBN/ISSN

0126-1312

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Pernyataan Tanggungjawab

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