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Histocompatibility Evaluation of Combination of Gypsum with Carbonated Hydroxyapatite of Gypsum with Carbonated Hydroxypatite as Bone Substitutes in Subsutaneous Tissue

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Combination of gypsum with carbonated hydroxyapatite (CHA) has shown to improve bone healing process. Soft tissue biocompatibility test is required prior to clinical application of bone substitues since the materials contact with the soft tissues upon application and can cause severe inflammatory response. The aim of this study was to evaluate histocompatibility of gypsum compared to combination of gypsum CHA in subtaneous tissue Disks of gypsum and gypsum CHA were implanted on paravertebral subcutaneous tissue of 26 male Wistar rats. Histological section were stained with Hematoxylin Eosin then evaluated and scored with a histological grading scale for softtissue implants. A two-wey ANOVA was used to analyze the histomorphometrical result with 95% confidence interval (p

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Journal of the Medical Sciences:42(2)2011:62-70

Publisher

Yogyakarta : Faculy of Medicine Gajah Mada University., 2011

Collation

8p.

Language

English

ISBN/ISSN

0126-1312

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