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Aldose Reductase Genetic Polymorphism is a Risk Factor of diabetics Retinopathy Among type 2 Diabetes Mellitus in Yogyakarta

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Diabetes melitus (DM) is a metabolic syndrome characterized by hyperglycemia and glucose intolerance, due to insulin resistance, insulin deficiency, or both. Diabetics retinopathy (DR) is a DM complication due to retinal intolerance, due to insulin resistance, insulin deficiency, or both. Diabetics ratinopathy (DR) is a DM complication due to retinal abnormality, that causes vision reduction and even blindness. The association between DR and aldose reductase C- 106T (ALRC-106T) gena polymorphism has been reported in previous studes. This genetic polymorphism increases the sorbitol level inside erythroccyte in the retinal membrane that leads to weaknes of retinal capilary vessel and microaneursin. The aim of this study was to know the presence of ALR 106T gene polymorphism and its frequency distribution among diabetics Javanese patients in Dr. Sardjito General Hospital Yogyakarta, Indonesia. In addition, this study also aimed to analyze the difference of erythrocytes osmotic fragilty (EOF) among ALR genetypes in type 2 daiabetics patients with DR and without DR and without DR and to analyze whether ALR polymorpism is a risk factor of DR in type 2 diabetics patients. This was a case control study that involved 40 diabetic patients with DR as case and 40 diabetics patients without DR as control groups. The C-106T ALR polymorphism was determined by polymerase chain reaction fragment length polymophism (PCR-RFLP) method, Erythrocytes osmotic fraglity was analyzed using spectrophotometer. Genotype and allele distribution were analyzed using x₂ and other data were analyzed using independent t-test and Mann Whitney, with p

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Journal of the Medical Sciences:42(2)2011:57-63

Penerbit

Yogyakarta : Faculty of Medicine Gajah Mada University., 2011

Deskripsi Fisik

6p.

Bahasa

English

ISBN/ISSN

0126-1312

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

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Pernyataan Tanggungjawab

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