Aldose Reductase Genetic Polymorphism is a Risk Factor of diabetics Retinopathy Among type 2 Diabetes Mellitus in Yogyakarta | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Aldose Reductase Genetic Polymorphism is a Risk Factor of diabetics Retinopathy Among type 2 Diabetes Mellitus in Yogyakarta

Jujuk Anton Cahyono - Personal Name; Ahmad Hamim Sadewa - Personal Name; Tasmini - Personal Name;

Diabetes melitus (DM) is a metabolic syndrome characterized by hyperglycemia and glucose intolerance, due to insulin resistance, insulin deficiency, or both. Diabetics retinopathy (DR) is a DM complication due to retinal intolerance, due to insulin resistance, insulin deficiency, or both. Diabetics ratinopathy (DR) is a DM complication due to retinal abnormality, that causes vision reduction and even blindness. The association between DR and aldose reductase C- 106T (ALRC-106T) gena polymorphism has been reported in previous studes. This genetic polymorphism increases the sorbitol level inside erythroccyte in the retinal membrane that leads to weaknes of retinal capilary vessel and microaneursin. The aim of this study was to know the presence of ALR 106T gene polymorphism and its frequency distribution among diabetics Javanese patients in Dr. Sardjito General Hospital Yogyakarta, Indonesia. In addition, this study also aimed to analyze the difference of erythrocytes osmotic fragilty (EOF) among ALR genetypes in type 2 daiabetics patients with DR and without DR and without DR and to analyze whether ALR polymorpism is a risk factor of DR in type 2 diabetics patients. This was a case control study that involved 40 diabetic patients with DR as case and 40 diabetics patients without DR as control groups. The C-106T ALR polymorphism was determined by polymerase chain reaction fragment length polymophism (PCR-RFLP) method, Erythrocytes osmotic fraglity was analyzed using spectrophotometer. Genotype and allele distribution were analyzed using x₂ and other data were analyzed using independent t-test and Mann Whitney, with p

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Location name is not set Journal of the Medical Sciences:42(2)2011:57-63

A0002711

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Series Title: -
Call Number: Journal of the Medical Sciences:42(2)2011:57-63
Publisher: Yogyakarta : Faculty of Medicine Gajah Mada University., 2011
Collation: 6p.
Language: English
ISBN/ISSN: 0126-1312
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