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Pengaruh Terapi Kurkuminoid Ekstrak Rimpang Kunyit Dibandingkan dengan Natrium Diklofenak terhadap Fungsi Ginjal Penderita Osteoartritis

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Background: Osteoarthritis is a joint disease most often found in the community. Patients with osteoarthritis are frequently drink non steroidal anti inflammatory drugs such diclofenac sodium. Data has shown too many side effects of diclofenac sodium especially to the kidney function. A research data in Malang shows that people who use herbs were 476 persons in city area and 580 persons in distric area per thousand patients with arthritis. Curcuma domestica Val. is one of Asia's native plants used to make herbal medicine mainly used to reduce inflammation. The purpose of this study was to assess the safety of curcuminoid from Curcuma domestica Val. rhizome extract compared to diclofenac sodium to the kidney function of patients with osteoarthritis. Methods: This was a prospective randomized open and blinded evaluation (PROBE) study. Subjects with knee osteoarthritis were divided randomly into two groups: the group who received 30 mg 3 times daily of curcuminoid from Curcuma domestica Val rhizome extrac (curcuminoid group) and group who received 25 mg 3 times daily of diclofenac sodium (diclofenac group). Assessment of results including serum blood urea nitrogen (BUN) and creatinine level was performed before and after 4 weeks period of treatment. Data analysis compared the change of those levels in each group during the treatment period by student t test analysis. Results: In the curcuminoid group there was no significant decrease of serum BUN level (p=0.52) and there was a significant decrease of serum creatinine level (p=0.03). In the diclofenac group there was a significant increase of serum BUN level (p

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Detail Information

Series Title

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Call Number

Media Penelitian dan Pengembangan Kesehatan;21(4)2

Publisher

Jakarta : Sekretariat Badan Litbangkes., 2011

Collation

6p.

Language

ISBN/ISSN

0853-9987

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Media Type

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Edition

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Subject(s)

plants, medicinal
diclofenac
kidney
curcumin
OSTEOARTHRITIS.

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