PENGARUH PEMBERIANMINYAK JINTAN HITAM (Nigella sativa)TERHADAP KADAR ALT DAN AST PLASMA TIKUS PUTIH (Rattusnovergicus)MODEL HEPATOTOKSIK (ETANOL) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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PENGARUH PEMBERIANMINYAK JINTAN HITAM (Nigella sativa)TERHADAP KADAR ALT DAN AST PLASMA TIKUS PUTIH (Rattusnovergicus)MODEL HEPATOTOKSIK (ETANOL)

Ratna Juwita - Personal Name; Zaenuri Syamsu Hidayat - Personal Name; Lieza Dwianasari - Personal Name;

The active constituents of the volatile black seed oil (Nigella sativa),ymoquinone, was found to be hepatoprotective against ethanol induced hepatotoxicity via its antioxidant mechanism and anti-inflammatory features. This research was aimed to reveal whether ethanol influence on the plasma ALT and AST level, whether black seed oil influence on the plasma ALT and AST level of hepatotoxic (ethanol) rats
model, and also, how much black seed oil effective dosage that can decrease the increasing plasma ALT and AST level of hepatotoxic (ethanol) rats model. With experimental method and completely randomized design,24 male wistar rats (Rattus novergicus) were divided into 4 groups. Group I only received a single dose of
ethanol 2 ml/100gr body weight orally, while group II, III and IV received 0,5, 1, 2 ml/Kg body weight/day of black seed oil for 7 days then ethanol 2 ml/100gr body weight orally was induced. Plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured before and after black seed oil and ethanol administration. Data analysis methods were conducted with paired T test and one way
ANOVA which was followed by post hoc Tukey’s HSD. The result reveals that ethanol caused significant increase in plasma ALT level (p=0,000) and AST level (p=0,000). The use of black seed oil in various dosage (0,5, 1, 2 ml/Kg body weight) caused difference signi ficant increase in plasma ALT level (p=0,000) and AST level (p=0,000) of hepatotoxic (ethanol) rats model. 0,5, 1, 2 ml/Kg body weight of black seed oil was not the effective dosage that can decrease the increasing plasma ALT and AST level of hepatotoxic (ethanol) rats model

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Location name is not set Mandala of Health;5(2)2011:288-294

A0002359

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Series Title: -
Call Number: Mandala of Health;5(2)2011:288-294
Publisher: Purwokerto : FK. dan Ilmu Kesehatan (FKIK) Unsoed., 2011
Collation: 6p.
Language
ISBN/ISSN: 0216-3093
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): ETHANOL
ASTMA
NIGELLA SATIVA
Specific Detail Info: -
Statement of Responsibility: -

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