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EFEK PEMBERIAN EKSTRAK TEMPE KEDELAI (GLYCINE MAX) TERHADAP EKSPRESI CASPASE- 3 MENCIT GALUR C3H MODEL KARSINOGENESIS PAYUDARA

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Carcinogenesis process was a ffected by decrease in apoptotic activities marked by low Caspase- 3 expression. Soybean (Glycine max) tempe is a widely consumed permented food. Isoflavon content of tempe showed proapoptotic effect on cancer. The aim of this study is to know the effect of soybean tempe extract on Caspase -3 expression of C3H mice (Musmusculus) breast carcinogenesis model. This experimental study used post-test only control group design. Twenty-four C3H mice were inoculated with tumor and divided into four groups: 1 control group and three groups dministered by soybean tempe extract dose 12 mg/20gBW/day, 24 mg/20gBW/day, and 48
mg/20gBW/day for two weeks, stained by caspase-3immunohistochemistry and evaluated by
Allred score. Statistical analysis Kruskal-Wallis continued by Post hoc analysis Mann
- Whitney test used SPSS ver.15. Analysis result showed significant increase of casp
ase -3 expression (p=0,046) with difference between control group and group 1 (p=0,009), control and group 2 (p=0,361), control and group 3(p=0,834), group 1 and group 2 (p=0,834), group 1 and group 3 (p=0,203),and group 2 and 3 (p=0,199). From the result we can conclude that soybean tempe extract administration increase Caspase-3 expression with minimal effective dose 12 mg/KgBW/day

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Series Title

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Call Number

Mandala of Health, 5(2)2011:269-275

Publisher

Purwokerto : FK. dan Ilmu Kesehatan (FKIK) Unsoed., 2011

Collation

6p.

Language

ISBN/ISSN

0216-3098

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Media Type

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Edition

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Subject(s)

mice
breast neoplasms
soybeans
APOPTOSIS
CASPASES

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