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Kadar Antioksidan Rendah Meningkatan Risiko Hemolisis pada Neonatus

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Hemolysis in neonatal sepsis is caused by complement activation by inflammatory reactions in response to microbial invasion. Other causes include: physiological conditions, congenital erythrocyte disorders, immunological processes, oxidative stress, drugs and hemolysin. The aim of this study was to determine the correlation between antioxidant level and hemalysis in neonatal sepsis. Prospective observational study with a nested cose-control was done in 94 neonatal sepsis, consisted 47 cases (Positive hemolysis) and 47 controls (negative hemolysis). Hemolysis was positive if reticulacyteindex>3 on day 1 and 3. Risk factors examined were: antioxidant (GPx, vitamin E, vitamin C) and oxidant (MDA), hemolysin, MDA and GPx wre measured using spectrophotometry, vitamin C by colorimetric assay, vitamin E by ELISA, and hemolysin by blood agar medium. Data were analyzed using Chi-square, unpaired t-test, Mantel-Haenszed and logistic regression. The results showed low GPx level (75µ/ghb) and low vitamin E level (

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Jurnal Kedokteran Brawijaya:26(3)2011:180-184

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Semarang : Fk. Universitas Brawijaya., 2011

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4p.

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0126-9347

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