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Perbandingan Efek Ranitidin, Dexametason dan Kombiasinya terhadap Kadar Asam Format Darah dan Pelepasan Sitokrom C Ratina pada Model Tikus Intoxication Rat Model

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Methanol intoxication can cause visual tozicity. Formic acid is a metabolite responsible in metabolic acidosis leaing to mitochendrial damage reflected in C. Sitorom release. This study is aimed to identify the effect of rantidine, dexamtehasone and their combination on blood formic acid level and retinal cytochrome c release of rats as acute methanol indoxication model. An experimental study was performed using post only with control group There were three treatment group i.e. ronitidine, dexamethasone and their combinations with two control groups i.e, normal untreated rats as negative control and untreated methanol intoxicated rats as positive control. Seven replications were applied on each group. Objects were intoxicated with oral delivery of methanol and received intraperitoneal delivery of ranitidine, dexamethasone and both at the designated doasge and time. Afterward, the blood formic acid level and cytochrome c release were abserved. Formic acid level of control and treated groups were quantified by colorimetric method using blood serum samples. Data were analyzed by one-way ANOVA with post hoc test to indentify the specific differences. The result demonstrated that the average of blood formic acid levels on method intoxicated rats, as positive control using blood serum samples. Data were analyzed by one way ANOVA with post hoc test to identify the specific differences. The result demonstrated that the overage of blood formic acid levels on method intoxicated rats, as positive contro, (10441.8 mg/mL) were much higher than that on normal untreated rats, as negative control (3612.6 mg/mL). Ranitidine therapy show highest decrease on the average of blood formic acid level into 2341.6 mg/mL, compared to dexamethasone therapy (5919.2 mg/mL or even the combination therapy (2913.2 mg/mL). Moreover, investigation on retinal cytochrome c release reveated a significant difference between the average volue of positiev control groups which were 18278.28 and 1680.74, respectively Ranitidine therapy delivered the highest reduction value of retinal cytochrom c release. (1202.06) compared to dexamethasone (2542.80) or the combination of both therapy (1670.23), it can be concluded that ranitidine worked through decreasing blood formic acid level and retinal cytochrome c value and has highest-effect, followed by combination and dexamethasone in methanol intoxication.

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Jurnal Kedokteran Brawijaya:26(3)2011:171-175

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Malang : FK. UniversitasBrawijaya., 2011

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5p.

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02169347

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