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Kaalsitonin Menurunkan Darejat Apoptosis Kondrosit Tulang Rawan Sendi dengan gangguan Biomekanik Instabilitas

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There are in vivo and in vitro experimental evidences that calsitonin, on anti resorptive agent that widely used for osteoporosis treatment, acts on both cartilage and subshondral bone by decreasing the enhanced turnover of the osteoarthritis (OA) subchondral bone, reducing the severity of cartilage OA lesions and altering the biochemical composition of the OA cortilage matrix. The exact mechanisms of how calcitonin works in OA treatment are not fullyunderstood. Cahondrocytes apoptosis has been associated with cortilage motrix depletion in OA. The aim of this study is investigate the effect calcitonin on decreasing chondrocyte apoptosis in biomechanicall y unstable joint. Robbits were divided into 3 groups. Left knee instability was created by sectioning the anterior crucilate ligment (ACLT) and meniscectomy on group 1 and group 2. Group 1 and gorup 2 were treated with daily injection of salmon calcitonin and normal saline (placebo) respectively for 6 weeks. Sham operation was performed on group 3 as control group. After 6 weeks, all the animals were sacrificed and cartilages were harvested from both fermoral and tibial side of knee joint for apoptosis examiation. Mechanical instability increased chondrocyte apoptosis significantly on both fermoral and tibial side of the joint (p

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Ketersediaan

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Judul Seri

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No. Panggil

Jurnal Kedokteran Brawijaya:26(3)2011:156-160

Penerbit

Malang : Fk. Universitas Brawijaya., 2011

Deskripsi Fisik

4p.

Bahasa

ISBN/ISSN

0216-9347

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