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Efek Estrak Kacang Tunggak terhadap Osteoblas pada Tikus dengan Ovarektomi

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After menopause, women loss the protective effect of estrogen, 50 that process of bone remodelling is altered and osteoporosis begins. This study investigas whether genistein in blockeved peas extract can act as phytoestrogen and become estrogen-repiacement-therapy alternative in ovariectomized rats. In this study, there were 6 groups: the first group is normal control rats (K-neg), the second group is ovariectomized rats which are kept for 1 month (k-pos 1), the third group is ovariectomized rats which are kept olive for 2 months (k-pos2), the fourth group is ovariectomized rats which are kept olive for 1 month and given blackeyed peas extract 0.5 ml/kaBW (k-1), the fifth group with dosage 2,5 ml/kgBw (K-2), and the sixth group with dosage 5 ml/kgBW (K-3). Distal femoral bone of each rat was taken and stained using Hematoxillin-Eosin. The quantity of osteoblast and osteoclast were counted from 20 visual fields with 1000x magnitude using Microphoto Microsvope Olympus and then overaged out. Data was analized using One Way ANOVA. The overage quantity of osteoblast and osteoclast was significant up higher in K-1 and K-2 compared to K-pas 2. The overage quantity of osteoclast was significant up lower in K-1,K-2, and K-3 compare to K-pos2. It can be concluded that blackeyed peas extract can increase the quantity of osteoblast and decrease the quantity of osteoclast in the ovariectomized rats.

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Call Number

Jurnal Kedokteran Brawijaya,26(3)2011:151-151-155

Publisher

Malang : FK. Universitas Brawijaya0216-9347., 2011

Collation

5p.

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ISBN/ISSN

0216-9347

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Subject(s)

rats
Osteoblasts

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