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Effectivity of 0.15% benzydamine on radiation-induced oral mucositis in nasopharynx carcinoma

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Background: Nasopharynx carcinoma is the most common malignant tumour in head and neck region. Radiotherapy is the first choice of treatment for nasopharynx carcinoma that had not been metastases. The most common oral complications in radiotherapy is mucositis (± 80%). 0.15% benzydamine hydrochloride (HCl) oral rinse can be used to prevent radiation-induced oral mucositis. Purpose: The aim of this research was to study the effectivity of 0.15% benzydamine HCl oral rinse for prevention of radiation-induced oral mucositis in nasopharynx carcinoma. Methods: Samples were divided into 2 groups. Group A was using 0.15% benzydamine HCl oral rinse for 10 days. Group B was using placebo oral rinse for 10 days. Evaluation was conducted 3 times: first day, fifth day and tenth day of radiotherapy. The scoring used Spijkervet’s mucositis α score. Results: Independent t test analysis for initial occurrence of oral mucositis showed no significant difference between 2 groups. Paired t test analysis showed significant difference between initial mucositis α score and mucositis α score in tenth day in each group. Independent t test analysis showed no significant difference in mucositis α score in tenth day between 2 groups. Conclusion: In conclusion 0.15% benzydamine HCl oral rinse was not effective to prevent radiation-induced oral mucositis in nasopharynx carcinoma

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Detail Information

Series Title

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Call Number

Dental Journal,44(2)2011:88-92

Publisher

Surabaya : Erlangga University Press., 2011

Collation

4p.

Language

English

ISBN/ISSN

1978-3728

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Content Type

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Media Type

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Edition

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Subject(s)

NASOPHARYNX
RADIATION
STOMATITIS
BENZYDAMINE

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