Expression of Matrix Metalloproteinase-8 Gene in Fixed orthodontic Patients | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Expression of Matrix Metalloproteinase-8 Gene in Fixed orthodontic Patients

Susilowati - Personal Name; Mansjur Nasir - Personal Name; Imam Mudjari - Personal Name; Thalca Hamid - Personal Name;

Background: Orthodontic treatment with fixed apliance produces structural and biochemical changes and breeding the balance between the synthesis and the breakdown of the collagen in the periodontium. Matrix metalloproteinase-8 (MMP-8) plays an importantrole in the remodeling of periodontal ligament during orrhodontic movement. Purpose: The purpose of this study was to observe the expression MMP-8 gene in the singival cervicular fluid (GCF) of fised orthodontic patients. It is expexted that the result can be used as a reference to decide the proper time for clastomeric chain to be reactivated. Methods: Orthodontic fixed appliances were placed on 8 patients and clatomeris chains exerting 75 grams were atached to produce camine distalization. GCF samples were collected from the distal side of upper canines before force application, 1.2.3-and4 weeks after application consecutively. The samples were analyzed by using RT-PCR. Statistical analyses used were univariate analysis and Mann-Whitney U test. Result: The expression of MMP-8 in the GCF at t0 was 31.3% but the foce application elevated its expression to 65.6% at t₁, and then decreased continously at t2,t3,t4. There was no statistically significant difference of MMP-8 gene expression betwen t0 and t3. Conclusion; The highers level of MMP-8 gene expression due to orthodontic forces was occured in the first week, but it declined continously in the following weeks. The proper time to reactivate an elastomeric chain was 3 weeks after application.

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Location name is not set Dental Journal:44(1)2011:54-58

A0002283

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Series Title: -
Call Number: Dental Journal, 44(1)2011:54-58
Publisher: Surabaya : Erlangga University Press., 2011
Collation: 4p.
Language: English
ISBN/ISSN: 1978-3728
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): orthodontics
PATIENTS
MATRIX METALLOPROTEINASE 8
Specific Detail Info: -
Statement of Responsibility: -

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