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TNAlpa Expression on Rats After Candida Albicans Inoculation and Neem (Azadirachta) Extract Feeding

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Neem is a known traditional medicine from trees which function as immunomodulator. Candidiasis found in month is 80% caused by Candida albicans (C albicans). Immunity is importhan to limit C. Albicans since medicine is relatively traditional medicine may became a good choice. In the other side the medicine price may not be reached by the citizen, cause citizen choose the traditional medicine. Purpose: The research is aimed to explain of TNF-α expression on rats after included by C. Albicans and fed with neem extract (Azadirachta Indica). Methods: There were 5 groups, the first group which was colled as control group (KO) hadn’t been fed aqueous extract from neem leaves and was not inoculated by C. Albicans, the other group (treatment)was classified into 4 groups. The first group was inoculated by C. Albicans only (KPI) second group was fed with 50 mg/day/kg body weight aquens extracts from Neem leaves, then inoculated with C. Albicans sturting from day 8 until day 21 (KP2), thrind group was fed with 100 mg/day/kg body weight aqueous extract from Neem leaves then moculated with C albicans from day 8 until day 21 (KP3) fourth group was fed 200 mg/day/kg body weight aqueous extract from Neem leaves, then inoculated by C albican startfrom day 8 until day 21 (KP4). The data was collected from by swabbing the rat’s tongue to calculate C. Albican colonic. The rats were acclimated and collected for immunothistochemistry measurement. Results: The study showed that there were different result on ANOVA, HSD test, and linier regression. ANOVA showed significant difference (p

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Dental Journal:4(1)2011:49-53

Publisher

Surabaya : Airlangga University Press:., 2011

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4p.

Language

English

ISBN/ISSN

1978-3728

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