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Biomarker Fibrosis Hati

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Fibrosis is nonspecific response to injuries which implies the synthesis of an extracelular matrix (ECM). The assessment of liver fibrosis affords information for diagnosis, therapeutic decision prognosis and monitoring the natural history of the disease. Although needic biopsy of the liver is the gold standard for fibrosis assessment, it has some limitations and complications. This lead to the development of noninvasive biomarkers of liver fibrosis; direct markers which reflect extracellular matrix turnover and indirect merkers which reffect alteration in hepatic fanction. Direct markers associated with matrict deposition or degradation and same cytokines implied in fibrosis may be used as individual merkersor or markers as as combination of markers to evaluated the stage of fibrosis. Fibrosis can also be predicted by using indirect markers as a single routine laboratory test or combination tests. Serum markers have great value as a part of the assessment of patients with chronic liver disease avoiding the invasive methods.

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Mandala of Health:5(1)2011: 268-274

Publisher

Purwokerto : FK. Ilmu-Ilmu Kesehatan (FKIK) Unsoed., 2011

Collation

4p.

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ISBN/ISSN

0216-3098

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