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Mekanisme Resistens Kortikosteroid Pada Asma

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Asthmatic patients have a specific patterm of airway inflamation that underlies the clinical features. Corticosteroids known to be useful for controling asthma and have a mojor effect in reducting inflammation of the airway well, suppress the expression of various genes in the airway inflamation and repair the bronhial hyperresponsiveness. However, a few asthmatic patients show a poor or absent response even to high doses of corticosteroid Knowing the mechanisms of carticosteroids resistence in asthma may lead to provide a better understanding on the management of corticosteroid resistant asthma. Molecular mechanisme of corticosteroid resistance include abnormalities in ligand binding and transiocation of the nucleus, decreased expression and or co-respressor protein activity or increased expression of inflammatory transciption factors

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Jurnal Respirologi Indonesia, 31 (4) 2011 : 210-22

Penerbit

Jakarta : Perhimpunan Dokter Paru Indonesia., 2011

Deskripsi Fisik

13p.

Bahasa

ISBN/ISSN

0853-7704

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

asthma
adrenal cortex hormones

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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