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Perubahan Parameter Biokimia pada Demam Dengue

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Dengue fever (DF) is still a health problem in Indonesia where primary DF gives less symptom then secondary DF. DF patients shows alterations of biochemical parameters such as increases in transaminase enzymes, bilirubin, phosphatase alkaline, gamma glutamil transferase (GGT), ureum, creatinine, uric acid and triglycerides level. Decrease in total protein, albumine, total and HDL cholesterol level. We aimed to study these biochemical parameters changes in primary and secondary DF. Using retrospective study through medical records from several hospitals in Malang during January 2006 until April 2010. Primary and secondary DF were distinguished using IgG & IgM Immunochromatography dengue Rapid Test (ICT DFRT). Secondary DF was characterized by positive Ig G result with or without positive Ig M ICT-DRFT, while primary DF (group II) was characterized by positive Ig M ICT DFRT only. Biochemical parame­ters data were examined using chemical auto analyzers, then analyzed with student t-test & ANOVA using SPSS 17 with degree of confidence p < 0.05.

There are DF 2287 cases that comprised into group I (1833 cases), and group II (454 cases). Although the number of cases were not same for each parameters. Biochemical parameter alterations in dengue virus infection were SGOT > 2 URL 58.71%, SGPT >2 URL 39%, Gamma GT >2 URL 32.01%, phosphatase alkalin­e 2URL 3.21%, total bilirubine > 2.0 mg/dl 7.94%, ureum > 100 mg/dl 5.60%, creatinine > 2.0 mg/dl 6.04%, uric acid > 6 mg/dl 19.04%, triglycerida > 150 mg/dl 51.97%, fasting blood glucose > 126 mg/dl 21.81%, and blood glucose post prandial > 200 mg/dl 11.86%. Decrease of total protein < 6.5 g/dl 84.94%, albumine

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Medika:37(6)2011: 388-394

Penerbit

Jakarta : PT. Grafiti Medika Pres., 2011

Deskripsi Fisik

6p.

Bahasa

ISBN/ISSN

0216-0910

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Pernyataan Tanggungjawab

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