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Perbandingan Gambaran Urinalisis dan Tes Faal Ginjal Dengue Primer dan Sekunder
Dengue Fever (DF) is still be a public health problem in Indonesia where primary DF usually gives less symptoms then secondary DF. The difference between primary DF and Secondary DF can be made by measuring of Ig G and Ig M level in patients’ blood specimen with Immunochromatography Dengue Fever Rapid Test (ICT-DFRT).
DF gives various abnormalities esuch as renal injury, creatinine increases, proteinuria, glomerulonephritis, hemolytic uremic syndrome. Proteinuria and abnormal urinary sediment are the most common manifestations in DF. The objective of the study is to compare and observe the differences of urinalysis profiles and renal function in primary DF and secondary DF. Methods: Retrospective study was conducted using secondary data of medical records from some hospital in Malang during periods of January 2006 until February 2010. Primary DF and secondary DF were distinguished using Ig G & Ig M with ICT-DFRT. Secondary DF was divided into group 1: positive Ig G and Ig M, and group 2: positive Ig G but negative in Ig M, while primary DF (group 3) was derived from positive Ig M only. Urine examination was conducted using dipsticks test & urinary sediment, renal functions test was conducted using clinical chemistry auto analyzers. Results were analyzed using student t test & ANOVA using SPSS 17 with degree of confidence p < 0,05.
Results: Laboratory test results shows a significant differences between group 1, 2, 3 in proteinuria (p 4 /pf) was 25.91%, 26.36%, 20%, and 25.96% respectively. Lekosituria (leucocytes count > 4/pf) was 24.03%, 25.45%, 25.37%, and 24.20% respectively. Creatinine serum shows significant difference only in I vs 2 groups (secondary dengue) with p = 0.024 (p < 0.05). Conclusion: There are significant differences in laboratory profiles between primary DF and secondary DF in proteinuria (p< 0,05). Negative proteinuria found higher in primary than secondary DF. Therefore, it is advised to perform urinalysis and renal function test if needed.
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