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Uji Toksisitas Akut Ekstrak Etanol Daun Klausena (Clausena anisata Hook.f.)

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The leaves of klausena plant (Clausena anisata Hook. F), belongs to Reutaceae family has been used by the people in West Sumatera and Java to treat the pain, like headache, toothache, rheumatism and fever. The used of this medicinal plant is not recognized clinically, because it has not been tested scientically, primary about it’s pharmacological activity and safety. Because their safety has not been proven, therefore this research has been done for knowing the lethalic dose 50(LD50) of ethanolic extract from the leaves of klausena in rats. The experimental laboratoric research has been done, using Completely Randomized Design (n= 5) and as experimental used male and female rats (Rattus norvegicus). Wistar strain, fine, approximately 2 months age and weighed 200 g. Six groups of rats has been treated orally with the ethanolic extract from the leavesof klausena (Clausena anisata Hook.1) in five level doses(o,55 mg. 1,1 mg, 4,4 dan 8,8 mg/200 g Body Weight of rat). The result showed 3 rats at dose 4,4 mg/200g and 5 rats at doses 8,8 mg/200g Body Weight or rat were died. The obtained indicated the ethanolic extract from the leaves of klausena is not toxic in rats and the value of lethalic dose is 17036, 85 mg/kg Body Weight, orally. Microscopically, at the high dose on xperimental animal primary organ has been found some changes, like degeration, microses and bleeding of cells

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Series Title

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Call Number

Jurnal Kedokteran Syiah Kuala, 11 (1) 2011 : 1-6

Publisher

Banda Aceh : FK. Universitas Syaih Kuala Darussalam Banda Aceh., 2011

Collation

6p.

Language

ISBN/ISSN

1412-1026

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

ETHANOL
ACUTE TOXICITY TEST
RUTACEAE

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