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Multimicronutrient supplementation in older persons decreased zinc deficiency but not serum TNF-α α α α

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The increase in the population of older persons needs to be accompanied by increased quality of healthcare in older persons, particularly a decrease in the incidence of infections. Impaired immune responses are common in older adults,and immune senescence likely contributes to the increased incidence of infectious diseases in the older persons. The aging process decreases the immune response
and many studies have been conducted to explain the role of supplementation with various icronutrients, such as vitamin C, vitamin E,β-carotene and zinc,on the immune response. The aim of the present study was to assess the influence of 6 months of multi-micronutrient (MMN) supplementation on zinc and tumor necrosis factor (TNF-α) levels in older persons. A randomized controlled trial
was conducted on 78 older persons, who were divided into two groups. The treatment group received MMN supplementation containing 40 mg elemental zinc, 120 mg ascorbic acid, 6 mg β-carotene, 15 mg α
-tocopherol and 400 μg folic acid and the control group 400 mg calcium carbonate. The study did not
demonstrate that 6 months of MMN supplementation resulted in significant differences between both groups, with respect to total protein, albumin, globulin, and TNF-α levels. In contrast, MMN supplementation significantly decreased the proportion of older persons with zinc deficiency in the treatment group, in comparison with the control group. The present data suggest that in older persons
with relatively good immune and protein status, improvement of the immune status by MMN upplementation may be difficult and at best limited

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Detail Information

Series Title

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Call Number

Universa Medicina, 30(2)2011:102-110

Publisher

Jakarta : USAID Jakarta., 2011

Collation

8p.

Language

English

ISBN/ISSN

1907-3062

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

zinc
AGED
SERUM
MICROMICRONUTRIENTS
MICRONUTRIENT

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