Genotype distribution of T cell receptor β gene in Indonesian nasopharyngeal carcinoma patients | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Genotype distribution of T cell receptor β gene in Indonesian nasopharyngeal carcinoma patients

Yurnadi - Personal Name; Nukman H. Moeloek - Personal Name; Dwi A Suryandari - Personal Name; R. Susworo - Personal Name;

Background: Nasopharyngeal carcinoma (NPC) is a multifactorial genetic disease, characteristically endemic and shows considerable differences in its geographical distribution. Besides infection with EBV, genetic factors such as polymorphisms of TCR-β gene contribute to the incidence of NPC. This study investigates the association of TCR-β gene polymorphisms with individual susceptibility to develop NPC in Indonesian ethnic groups.

Methods: The study was carried out by the PCR-RFLP method using Bgl II restriction enzyme to digest TCR-β gene. The PCR-RFLP analysis of TCR-β gene was used to determine allotypes of TCR-β gene in NPC patients and control among ethnic Chinese and indigenous groups in the population of Indonesia.

Results: The results indicate that the distribution of TCR-β gene allotypes between NPC patients and controls are not significantly different (p > 0.05); however, the frequency of A allele tends to increase in NPC patients. The distribution of TCR-β gene allotypes between Chinese ethnic group was not signifi cantly different from indigenous groups (p > 0.05).

Conclusion: The distribution of TCR-β gene allele between NPC group and control groups showed no difference. The distribution of TCR-β gene between ethnic Chinese and indigenous groups showed no difference. Polymorphisms of TCR-β gene are not associated with NPC and ethnic groups in Indonesian population. (Med J Indones 2011; 20:171-7)

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Location name is not set Medical Journal of Indonesia:20(3)2011:171-177

A0002089

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Series Title: -
Call Number: Medical Journal of Indonesia:20(3)2011:171-177
Publisher: Jakarta : Universitas Indonesia., 2011
Collation: 7p.
Language: English
ISBN/ISSN: 0853-1773
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): GENOTYPE
NASOPHARYNGEAL NEOPLESMA
GENES,TCELL PERCEPTOR BETA
Specific Detail Info: -
Statement of Responsibility: -

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