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The metabolic effects of di (2-ethyl hexyl) phthalate medium dose on lipid profiles in serum and liver tissue

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Background: Di (2-ethyl hexyl) phthalate is the most widely used plasticizer in blood storage bag for transfusion. This substance can modify lipid metabolism. This study was aimed to elucidate the metabolic effects of di (2-ethyl hexyl) phthalate medium dose on lipid profiles in serum and liver tissue.

Methods: Sprague Dawley rats were fed 1.0 % di (2-ethyl hexyl) phthalate diet (DEHP group, n=5) or a non-supplemented diet (control group, n=5) for 10 days. The rats were allowed to freely access each food. Serum lipid concentrations were measured using enzyme assay kits. Lipids of liver tissues were extracted and the lipid contents were determined. A peach of liver was prepared to determine the activities of malic enzyme and carnitine palmitoyl transferase-1 (CPT-1).

Results: Serum lipid concentrations (mg/dL) of DEHP group decreased compared to control (P

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Medical Journal of Indonesia:20(1)2011:20-26

Penerbit

Jakarta : Universitas Indonesia., 2011

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

0853-1773

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

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Info Detail Spesifik

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Pernyataan Tanggungjawab

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