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Efek Pemberian Niasin terhadap Glukosa Darah pada Tikus Wistar dengan Obesitas

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Niacin has many controversies about its effect to the management of the blood glucose. The objective of the research was to know the effect of niacin to the blood glucose in obese wistar rats. This research was an experimental laboratory study with a parallel design using randomization. Male Wistar rats were used in this research. All rats
were induced to be obesed with high-fat feeding for 10 weeks. Rats that fulfill the criteria were randomly divided into two groups. The first group was given the placebo. The second group was given the niacin. The niacin and the placebo were given for the next 20 days. The niacin dose was 0.135 mg/g body weight/day. Fasting blood glucose (FBG) and oral glucose tolerance test (OGTT) were taken on the 21st day. The results showed that there were not any significant differences in FBG and OGTT between control and treated group. The FBG of the niacin group was 4.0 mg/dL (95% CI -0.342–8.4) lower than the control group, with p=0.068. The OGTT result of the niacin group was 0.8 mg/dL (95% CI -5.6 –7.1) higher than the control group, with p=0.800. This study concludes
that taking niacin does not cause differences in FBG and OGTT results in the male Wistar rats with diet induced obesity. [MKB. 2011;43(1):16–20].

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Majalah Kedokteran Bandung, 43(1)2011:18-20

Penerbit

Bandung : FK.UnirsitasPadjjaran., 2011

Deskripsi Fisik

5p.

Bahasa

ISBN/ISSN

0126-074X

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

obesity
BLOOD GLUCOSE
RATS, WISTAR

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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