Konsumsi Antioksidan dan Ekspresi Gen eNOS3 Alel-786T>C pada Penderita Hipertensi Etnik Minangkabau | Perpustakaan dan Galeri Kebijakan Kesehatan

Pencarian berdasarkan :

SEMUA Pengarang Subjek ISBN/ISSN Pencarian Spesifik

Pencarian terakhir:

Text

Konsumsi Antioksidan dan Ekspresi Gen eNOS3 Alel-786T>C pada Penderita Hipertensi Etnik Minangkabau

Delmi Sulastri - Nama Orang; N.I. Liputo - Nama Orang;

Gene of eNOS 3 allel -786T>C is one of the important genes which is related to the high prevalence of hypertension. Polymorphism of this gene decreases nitric oxide synthase (NOS) enzyme synthesis result in reduction of nitric oxide (NO). Nitric oxide causes vasodilatation, which decreases peripheral resistant and blood pressure. The aim of this study was to evaluate the influence of an antioxidant consumption on eNOS3 gene -786T>C allel expression in hypertension patients with Minangkabau ethnicity. Cross sectional study was done on 130 hypertension and normotension subjects, 30–65 years old in 4 districts, Padang, Sumatera Barat during 2009. The interview about
antioxidant consumption by food frequency questioner, the assessment of eNOS3 gene by polymerase chain reaction and NO plasma level by enzyme linked immunosorbent assay were done. The data were analyzed using t-test and chi-square. The results showed that the hypertensive’s and normotensive’s plasma NO concentration were 26.91±15.40 μM/L and 25.79±15.04 μM/L, respectively. There were thymine to cytosine substitution found at 786 position in 1.5% of the hypertensive subjects and 9.2% of the normotensive subjects. A low plasma NO levels (67.2%) was found in subjects with heterozygote TC alleles.There was a significant relationship between consumption of antioxidant (vitamin E) and NO plasma level in hypertension subjects with TC heterozygote allel. In conclusions, vitamin E influences NO plasma level in hypertension patients with heterozygote TC alleles.

Ketersediaan

Belum memasukkan lokasi Majalah Kedokteran Bandung:43(1)2011:1-9

A0002046

Tersedia

Informasi Detail

Judul Seri: -
No. Panggil: Majalah Kedokteran Bandung, 43 (1) 2011 : 1-9
Penerbit: Bandung : FK. Universitas Padjadjaran Bandung., 2011
Deskripsi Fisik: 9p.
Bahasa
ISBN/ISSN: 0126-074X
Klasifikasi: NONE
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: antioxidants
hypertension
GENE EXPRESSION
Info Detail Spesifik: -
Pernyataan Tanggungjawab: -

Versi lain/terkait

Tidak tersedia versi lain

Lampiran Berkas

Tidak Ada Data

Komentar

Anda harus masuk sebelum memberikan komentar