Konsumsi Antioksidan dan Ekspresi Gen eNOS3 Alel-786T>C pada Penderita Hipertensi Etnik Minangkabau | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Konsumsi Antioksidan dan Ekspresi Gen eNOS3 Alel-786T>C pada Penderita Hipertensi Etnik Minangkabau

Delmi Sulastri - Personal Name; N.I. Liputo - Personal Name;

Gene of eNOS 3 allel -786T>C is one of the important genes which is related to the high prevalence of hypertension. Polymorphism of this gene decreases nitric oxide synthase (NOS) enzyme synthesis result in reduction of nitric oxide (NO). Nitric oxide causes vasodilatation, which decreases peripheral resistant and blood pressure. The aim of this study was to evaluate the influence of an antioxidant consumption on eNOS3 gene -786T>C allel expression in hypertension patients with Minangkabau ethnicity. Cross sectional study was done on 130 hypertension and normotension subjects, 30–65 years old in 4 districts, Padang, Sumatera Barat during 2009. The interview about
antioxidant consumption by food frequency questioner, the assessment of eNOS3 gene by polymerase chain reaction and NO plasma level by enzyme linked immunosorbent assay were done. The data were analyzed using t-test and chi-square. The results showed that the hypertensive’s and normotensive’s plasma NO concentration were 26.91±15.40 μM/L and 25.79±15.04 μM/L, respectively. There were thymine to cytosine substitution found at 786 position in 1.5% of the hypertensive subjects and 9.2% of the normotensive subjects. A low plasma NO levels (67.2%) was found in subjects with heterozygote TC alleles.There was a significant relationship between consumption of antioxidant (vitamin E) and NO plasma level in hypertension subjects with TC heterozygote allel. In conclusions, vitamin E influences NO plasma level in hypertension patients with heterozygote TC alleles.

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Location name is not set Majalah Kedokteran Bandung:43(1)2011:1-9

A0002046

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Series Title: -
Call Number: Majalah Kedokteran Bandung, 43 (1) 2011 : 1-9
Publisher: Bandung : FK. Universitas Padjadjaran Bandung., 2011
Collation: 9p.
Language
ISBN/ISSN: 0126-074X
Classification: NONE
Content Type: -
Media Type: -
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Edition: -
Subject(s): antioxidants
hypertension
GENE EXPRESSION
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Statement of Responsibility: -

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