Gonadotropin Inhibitory Hormone (GnIH) Prevents the Priming Effect of Estradiol-17 betha | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Gonadotropin Inhibitory Hormone (GnIH) Prevents the Priming Effect of Estradiol-17 betha

Ika Puspita Sari - Personal Name; Iain Clarke - Personal Name; Alexandra Rao - Personal Name; Jessica Jacobi - Personal Name;

Gonadotro inhibits GnRH-stimulated gonadotropin secretion in the Sheep by action on the piltultary gonadotropes. Estradiol -17β (E₂) also at the level of the pitultary gonadotrope to exert negative and positive feedback effects on gonadotropin secretion. The positive effect facillitates the estrogen-induced surge in gonadotropin releasing hormone (GnRH) and LH. This study was undertakento determine whether this priming effect of E₂ is prevented by GnIH. Cultured pitultary cells were treated with GnRH or vehicle every 4 h for 24 h with and without GnIH and E₂ tretment. GnRH stimulated (LH) and follicle stimulating hormone (FSH) secretion was increased by E₂ treatment. The effect of E₂ was overcomes by the inhibitory effect of GnIH. We conclude that GniH may conteract the priming effect of E₂ on pitultary gonadotrepes

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Location name is not set Majalah Farmasi Indonesia; 22(3) 2011: 166-173

A000 1949

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Series Title: -
Call Number: Majalah Farmasi Indonesia; 22(3) 2011: 166-173
Publisher: Yogyakarta : Fakultas Farmasi UGM,., 2011
Collation: 7p.
Language: English
ISBN/ISSN: 0126-1037
Classification: NONE
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): gonadotropins
ESTRADIOL
Specific Detail Info: -
Statement of Responsibility: -

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