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Gonadotropin Inhibitory Hormone (GnIH) Prevents the Priming Effect of Estradiol-17 betha

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Gonadotro inhibits GnRH-stimulated gonadotropin secretion in the Sheep by action on the piltultary gonadotropes. Estradiol -17β (E₂) also at the level of the pitultary gonadotrope to exert negative and positive feedback effects on gonadotropin secretion. The positive effect facillitates the estrogen-induced surge in gonadotropin releasing hormone (GnRH) and LH. This study was undertakento determine whether this priming effect of E₂ is prevented by GnIH. Cultured pitultary cells were treated with GnRH or vehicle every 4 h for 24 h with and without GnIH and E₂ tretment. GnRH stimulated (LH) and follicle stimulating hormone (FSH) secretion was increased by E₂ treatment. The effect of E₂ was overcomes by the inhibitory effect of GnIH. We conclude that GniH may conteract the priming effect of E₂ on pitultary gonadotrepes

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Majalah Farmasi Indonesia; 22(3) 2011: 166-173

Penerbit

Yogyakarta : Fakultas Farmasi UGM,., 2011

Deskripsi Fisik

7p.

Bahasa

English

ISBN/ISSN

0126-1037

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

gonadotropins
ESTRADIOL

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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