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Kapasitas Jerap Niosom terhadap Ketoprofen dan Prediksi Penggunaan Transdermal (Niosomes Entrapment Capacity of Ketoprofen and Prediction Transdermal dministration)

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Niosomes are vesicles system that have applications in the delivery of lipophilic, hydrophilic and amphiphilic drugs. Ketoprofen, is very insoluble in water and cause gastric irritation when taken orally. It is very important to water and cause gastric irritation when taken orally. It is very important to develop a transdermal delivery system for ketoprofen. This research was aimed to design niosomes which can deliver katoprofen via transdermal route. Experiments were designed to incorporate ketoprofen into niosomes with lipid film hydration method. Lipid mixture consist of cholesterol and sorbitan ester(span 20, 60, 80). Niosomes which can deliver ketoprofen trough the skin barrier determined by calculating amount of ketoprofen in the blood of rabbit.The type of sorbitan ester was chosen based on the highest drugs entrapment and ketoprofen as drugs model. Preparation of nisomes was optimized for the highest percent drug entropment by increasing molar concentration of lipid mixture with the stable comparison of 1:1. This research result are niosomes with lipid mixture span 60 and cholesterol have the highest drug entrapment efficiency of niosimes 66.16% with range size 1-6 µm. Niosomes can deliverketoprofen to the systemic circulation via transdemal route with plasma level concentration achieved in 1.5 hour.

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Majalah Farmasi Indonesia: 22(2) 2011: 85-91

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Yogyakarta : Fakultas Farmasi UGM., 2011

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0126-1037

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