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Aktivitas Antihiperrurisemia Ekstrak Air Jinten Hitam (Coleus ambonicus Lour) pada Mencit Jantan Galur Balb-c Mice and its standardization (Antihypertensemia Activity of Water Extract of Black Seed (Coleus Ambonicus Lour) in Balb-c Mice and Its Standardization)

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Effect of water extract of black seed on uric acid metabolism in hyperuricemia mice models were studied. The influence of water extract of black hyperuricemia mice models were studied. The influence of water extract of black sed on uric acid biosynthesis was examined using mice treated by 250 mg/body weight potassium oxonate intra peritoneal. The result showed that water extract of black seed (200 mg/kg body weight, per oral) have a significant effect in reduction in plasma uric acid levels in comparison to negative control, but less active than positive control (allopurinol). The levels of usric acid in ice plasma for negative control, black seed extract and positive control were 3.00 ± 0.346mg/dL, 0.200 ± 0.100 mg/dL dan 1200 ± 0.100 mg/dL dan 1.200 ± 0.561 mg/DL, respectively. The standardization performed by determined specific and non specific parameters of water extract of black seed are phenolic content, and flavoid content are 0.664 ± 0.0.035% and 0.400±0.018%, respectively. Non specific parameters of water extract of blck seed are loss of weight, water content, ash content, ash insoluble acid content, , heavy mettals contamination (Pb and Cd), and aflatoxin residue are 14.93-14.93-14.99%, 6.09-7.12-7.49%, 5.20-6.66%, 6.405±0.211 ppm, 0.0096±0.not dtected, respectively

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Majalah Farmasi Indonesia; 22(2)2011:77--84

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Yogyakarta : Fakultas Farmasi UGM., 2011

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0126-1037

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