Text

Effect of Testosterone Deprivation on Smooth Muscle-Collagen Ration in Bladder Wall of Wistar Rat

---

To evaluate the smooth muscle-collagen fibers ratio in the bladder wall of castrated male wistar rats.Material & method: Sixteen wistar rats were equally assigned to castrated group (n = 8) and sham group (n = 8). All wistar rats were subjected to a one-week acclimatization period before undergoing treatment. After 60 days, cystectomy was performed in all rats in both groups and subsequent specimens of the bladder were taken to semi-quantitative pathology analysis using haematoxylin eosin (HE) staining under Olympus CX20® microscope by a uropathologist. Results were then grouped into parametric data and analyzed using independent T-test.
Results: Smooth muscle fibers were significantly lower in the castrated group 0,615 ± 0,13 (p = 0,01). There was higher amount of collagen fibers in the castrated group 0,385 ± 0,18 (p = 0,04). Smooth muscle to collagen ratio in the castrated group was also significantly lower compared to the control group 1,597 ± 0,25 (p = 0,03). Conclusion: Testosterone deprivation significantly reduces the smooth muscle and smooth muscle to collagen fibers ratio in bladder wall of castrated rats.

---

Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

Jurnal Urologi Indonesia,18(2)2011:31-35

Penerbit

Surabaya : Ikatan Ahli Urology Indonesia., 2011

Deskripsi Fisik

5p.

Bahasa

English

ISBN/ISSN

0853-4438

Klasifikasi

-

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

muscles
testosterone
RATS, WISTAR
COLLAGEN

Info Detail Spesifik

-

Pernyataan Tanggungjawab

-

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar