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Effect of Testosterone Deprivation on Smooth Muscle-Collagen Ration in Bladder Wall of Wistar Rat

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To evaluate the smooth muscle-collagen fibers ratio in the bladder wall of castrated male wistar rats.Material & method: Sixteen wistar rats were equally assigned to castrated group (n = 8) and sham group (n = 8). All wistar rats were subjected to a one-week acclimatization period before undergoing treatment. After 60 days, cystectomy was performed in all rats in both groups and subsequent specimens of the bladder were taken to semi-quantitative pathology analysis using haematoxylin eosin (HE) staining under Olympus CX20® microscope by a uropathologist. Results were then grouped into parametric data and analyzed using independent T-test.
Results: Smooth muscle fibers were significantly lower in the castrated group 0,615 ± 0,13 (p = 0,01). There was higher amount of collagen fibers in the castrated group 0,385 ± 0,18 (p = 0,04). Smooth muscle to collagen ratio in the castrated group was also significantly lower compared to the control group 1,597 ± 0,25 (p = 0,03). Conclusion: Testosterone deprivation significantly reduces the smooth muscle and smooth muscle to collagen fibers ratio in bladder wall of castrated rats.

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Detail Information

Series Title

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Call Number

Jurnal Urologi Indonesia,18(2)2011:31-35

Publisher

Surabaya : Ikatan Ahli Urology Indonesia., 2011

Collation

5p.

Language

English

ISBN/ISSN

0853-4438

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

muscles
testosterone
RATS, WISTAR
COLLAGEN

Specific Detail Info

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