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Comparison Between Glycogen Level Of Kidney Tabular Cells in Diabetic Kidney Stone Patients and Non Diabetic Kidney Stone Patients

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A higher prevalence of kidney stone in diabetes mellitus (34%) is probably caused by insulin resistance. Insulin resistance inhibits gluconeogenesis, which might be associated with a low urine pH that lead to stone formation.

Objective: To compare glycogen level of kidney tubular cells in diabetic kidney stone patients with in nondiabetic kidney stone patients.

Material & method: We reviewed kidney stone patients who underwent nephrectomy in Hasan Sadikin Hospital from February 2008 to January 2009. Age, gender, type of DM, and urine pH were recorded. Glycogen level of kidney tubular cells were evaluated histochemically using HE, PAS, and PAS diastase. The results were categorized into 3 grades, based on the staining appearance and using liver cells as control. The results of diabetic group were than compared to non diabetic patients.

Results: There were 30 patients eligible for this study, 15 in diabetic group and 15 non diabetic patients. In diabetic group, there were 10 patients with urine pH < 6 and 5 patients with a pH of 6,5. In the non diabetic group all urine pH were > 6,5. Examination revealed that glycogen level of kidney tubular cells in diabetic group was higher than in non diabetic group.

Conclusion: Glycogen level of kidney tubular cells in diabetic kidney stone patients was higher than in non diabetic kidney stone patients.

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Detail Information

Series Title

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Call Number

Jurnal Urologi Indonesia,18(1)2011: 27-30

Publisher

Surabaya : Ikatan Ahli Urology Indonesia., 2011

Collation

3p,

Language

ISBN/ISSN

0853-4438

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

KIDNEY CALCULI
PATIENT
GLYCOGEN

Specific Detail Info

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