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RelationShip Between P53 Expression and Probability of Organ Confinement in Patients With Prostate Cancer in Sardjito Hospital

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Objective: To determine the association between p53 expression and the level of organ confinement in patient with prostate cancer in Sardjito Hospital, Yogyakarta. Material & method: Prostate specimens were obtained from patients with clinical stage T1-T2 prostatic adenocarcinoma in Sardjito Hospital between January 2007 and December 2008. Samples were processed and immunohistochemically stained in the Department of Anatomical Pathology Gadjah Mada University. The probability of organ confinement were determined based on updated Partin table 2007 by combining preoperative serum PSA level, Gleason Score, and Clinical Stage. The correlation between p53 expression number and level of organ confinement were statistically analyzed by Spearman correlation test.
Results: There were 28 prostate cancer patients eligible for this study. The mean age was 65.19 ± 10.9(28 – 81) years old, the mean preoperative PSA level were 107.13 + 165.82 (0.20-734.20) ng/ml. The mean number of p53 expression were 97.47 + 97.27 (5-396)/HPF. Significant correlation were found between p53 expression and the level of organ confinement (Spearman r = -0.441; p = 0.019).Conclusion: p53 expression was negatively correlated with the level of organ confinement in patient with prostate cancer.




Correspondence: Indrawarman, c/o: Department of Urology, Faculty of Medicine/Indonesia University, Cipto Mangunkusumo Hospital, Jakarta. Home address: Jl. Kaliurang Km. 8, Banteng Baru IDI 39, Yogyakarta. Mobile number: 081393877717. Email: indrawarman@yahoo.com

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Filed under JURI Vol. 18. No.1 Januari 2011

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Indonesian Journal of Urology, 18(1)2011; 16-20

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Surabaya : Ikatan Ahli Urology Indonesia., 2011

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4p.

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English

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0853-4438

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Subject(s)

prostatic neoplasms
PATIENTS
TUMOR SUPPRESSOR PROTEIN P53

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