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Efek Klonidin sebagai Ajuvan Anestesi Spinal terhadap Kadar Glukose Darah

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Stress response to post-surgical pain can raise blood sugar level. Excessive blood sugar level (hyperglycemia) in turn may increase the risk of mortality. Intrathecal morphine as a spinal anesthesia adjuvant has shown effective to suppress blood sugar increase. However, morphine can
induce serious adverse effects such as respiratory distress. This study aimed to determine the effect of Clonidine as a spinal anesthesia adjuvant on blood glucose level and duration of analgesia. A randomized controlled trial was conducted in 30 patients undergoing lower abdominal
surgery with spinal anesthesia. The patients were randomly divided into 2 groups. The control group was given an anesthetic agent 12.5 mg of 0.5% Bupivacaine and 0.3cc 0.9% NaCl. The experimental group was given anesthetic agent 12.5 mg of 0.5% Bupivacaine and Clonidine 1mcg/ kg body weight. The primary outcome variable under study was blood glucose level before incision up to 12 hours after the end of operation. The side outcome variable was duration of analgesia. The effect of Clonidine was
reported in terms of OR, ARR, RRR, and NNT. The addition of Clonidine to Bupivacaine 0.5% spinal anesthesia stabilized blood glucose level.
Statistically significant lower level of blood glucose was demonstrated in subjects with Clonidine than those without Clonidine during the wound closure (p

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Detail Information

Series Title

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Call Number

Jurnal Kedokteran Indonesia,2(1)2011:45-50

Publisher

Surakarta : Fk. Universitas Sebelas Maret., 2011

Collation

5p.

Language

ISBN/ISSN

2086-5171

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

BLOOD GLUCOSE
ADJUVANT, ANESTHESIA
CLONIDINE

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