Karakterisasi Sifat Fisik Sistem Biner Eritromisin Stearat-Sodium Stract Glycolate Akibat Pengaruh Tekanan Kompresi (Characterization of Physical properties of Binary System of Erythromycin Stearate-Sodium Stract Glycolate by Compression Force Effect) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Karakterisasi Sifat Fisik Sistem Biner Eritromisin Stearat-Sodium Stract Glycolate Akibat Pengaruh Tekanan Kompresi (Characterization of Physical properties of Binary System of Erythromycin Stearate-Sodium Stract Glycolate by Compression Force Effect)

Dwi Setyawan - Personal Name; Yeyet C Sumitrapura - Personal Name; Sundani N Soewandhi - Personal Name; Daryono Hadi - Personal Name;

Characterization of th physical properties of binary system of eryhromycin stearate (ERS)-sodium starch glycolate(SSG) due to compression force, had been caried out. The solid state properties were evaluated by powder X-ray diffraction (PXRD), scanning electron microscope (SEM) and differentail thermal analysis (DTA) methods. The weight microscope (SEM) and differential thermal analysis (DTA) methods. The weight fraction of mixtures ERS: SSG (90:10), (80:30) were compressed using hydraulic press and flat plain punches with a diameter of 13 mm. The compression force was 29.5 KN. Diffraction peaks at 20=5.6 and 25.6⁰ were used to determine the full width at half maximum (FWHM), crystalite size and preferred orientation. Peak briadning was calculated by measuring the FWHM. FWHM values, crystalilite size and preferred orientation of the crystallites were calculated by WinPlotr program. The result of the study showed that the PWHM value increased at all the crystal lattice as the fraction of SSg increased. The crystalite size and peak intensity decreased gradually as fraction of SSG increased. Scaning Electron Microscope (SEM) analysis indicated that SSG was dispersed on surface and inside of the tablet of ERS at all combination. The phase diagram of binary system ERS and SSG showed a no interaction of ERS and SSG.

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Location name is not set Jurnal Kesehatan; 9(1)2011:82-88

A0001797

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Detail Information

Series Title: -
Call Number: Majalah Farmasi Indonesia, 22(1)2011:43-49
Publisher: Yogyakarta : Fakultas Farmasi UGM., 2011
Collation: 6p.
Language
ISBN/ISSN: 0126-1037
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): ERYTHROMYCIN
STEARATES
GLYCOLATES
Specific Detail Info: -
Statement of Responsibility: -

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