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Khitosan dan Kelainan Rangka Janin Mencit (Mus musculus)

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Abstract:
Chitosan has ability to repair chondrocyte tissue and damaged bone. The purpose of this research is to know whether the giving of chitosan on mice mother pregnant 10 days can decrease skeleton marphology malformation. This research used the post test only control group design with 28 experimental mice (Mus musculus) age 8-10 weeks with weight 20–25 g. Chitosan was given on dosages 15, 30 and 45 mg/kg of the weight, on one hour after retinoid acid was given with single dose 60 mg/kg of the weight to mice mother. On the 18 th days, experimental mice was laughtered and colored by Alizarin Red S and then morphology malformation and delay ossification retardation was identified. It can be concluded that chitosan with different dosage are not to skeleton morphology malformation of mice fetus. Meanwhile, the delay ossification of mice fetus with chitosan treatment on three dosages was different
significantly (p < 0.05) on sacrum and caudal bone, phalanges distal of forelimb and hindlimb

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Jurnal Kesehatan; 9 (1) 2011:35-44

Publisher

Malang : Poleteks Kemenkes Malang., 2011

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8p.

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1693-4903

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