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Pengaruh Ekstrak Etanol Akar Daruju (Acanthus illicifolius L.) terhadap Hepatosit Mencit Putih (Mus musculus L) yang Diinduksi Karbon Tetraklorida (The Effect of Ethanol Extract of Daruju Rooot (a. illiciofolius L.) on the Mice Hepatocyte Which is Induced by Carbon Tetrachloride)

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This research is conducted to analyze the effcet of ethanol extract of daruju root (A. Illiofollus L) on the mice hepatocyte which is inducted by carbon tetrachloride. Ethanol extract of daruju root is fed to the mice (per oral) with 250 mg/kg, 1000 mg/kg, and 4000 mg/kg weight dosage in 7 days. On day 8, the mice sample is given by carbon tetrachloride which is dissolved in olive oil. As negative control, the mice are administrated with aquades in 7 days and on day 8, olive oil is given. Meanwhile, as positive control, mice are given aquades in 7 days and on days 8, carbon tetrachioride is given. Measured parameter in this research is serum Glutamat Pirvate Transaminase (SGPT), diameter vena sentralis, Glutation Perroxidase (GSH-Px) and malonildialdhid IMDA). On day 11, all mice are killed and the blood is taken by means of heart puncture.The statistical analysis shows that there is treatment effect toward SGPT activites increasing to 1000 mg/kg weight dosage of ethanol extract of daruju root. In diameter of vena centralis, there is sighificant diifferent between negative control treatment and all treatments. There is no treatment effect on the activity of glutation Peroksidase and MDA.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Farmasains,1(3)2011:150-155

Penerbit

Jakarta : Puslitbang Ekologi Kesehatan,Badan Litbangkes., 2011

Deskripsi Fisik

6p.

Bahasa

ISBN/ISSN

2086-6968

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

mice
plant extracts
ETHANOL
CARBON TETRACHLORIDE
ACANTHACEAE

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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