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Formulasi Asi Mukoadhesif Nifedipin Menggunakan Kombinasi Polimer Carbopol 943 dan Gelatin Type B (The Mucoadhesive Formulation using Polymer Combination of 934 Carbopol and Type B Gelatin)

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Mucoadhesive strangth test of polimer exipient is important for development of oral sustained release with mucoadhesive system to increase bioavailability. Mucoadhesive strangth of niphedipine graule which is preparared by using combination of polymers gelantin and carbopol 934 on rat stomach and intestine had been determined by bioadhesion and wash off test. In the research the various effect of gelatin concentrations on the mucoadhesive strength was determined. Mucoadhesive strength test was cunducted with gelatin 2%,3%,4%,5% and as a control carbopol 934 was used. The study started with the evaluation of characteristics of niphedipine particles with ball mill size. Evaluation of characteristics of the test were with DCS, IR, X-rRay and then than was followed by the preparation of granule mucoadhesive niphedipine. The evaluation were granules, bioadhesive test, wash of test and dissolution test. Result showed that F 4 with 5% gelatin could be adhesive to rat stomach and intestine in 5 minutes. The strongest adhesion to stomach and intestie were the granule combination of gelatin 5% and carbopol 934 5% with the amount of granule adhesive to stomach and intestine were 94,67% and 98%. Results indicated that the dissolution profil of all the formula did not follow either zero order, first order. The result showed that released of niphedipine from all formulation has followed higuchi kinetics.

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No. Panggil

Farmasens:1(3)2011:144-149

Penerbit

Jakarta : Universitas Muhammadiyah Prof Dr. Hamka., 2011

Deskripsi Fisik

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Bahasa

ISBN/ISSN

2086-6968

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