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Expresi Protein Caspase-9 dan Gambaran Histologi Paltum sekunder Mencit Prenatal Akibat Paparan Diazepam di Periode Organogenesis (Caspase-9 Protein Expression and Description of Histologic Secondary Palate on Prenatal Mice Caused by Exposure to Diazepam in the Period of Organogenesis)

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The aim of this research at evaluation of the teratogenic effect of diazepam intake in the pariod of organogenesis to caspase -9 expression and histology study on secondary palate development. The different steps of palatogenesis were tigntly regulated and failure of palatal shelves growth, elevation, contact, and or fusion generate a cieft palate. Cleft palate is one of the most common congenital malformations. A bout 18 mices (Mus musculus) of known age and weight were used. They were deivided in two groups: The first groups were control group which were injected daily with distilled water, while the second groups were injected daily with diazepan 8 mg/kg/day. Anomalies of cleft palate were evaluated. The histology results with diazepam 8 mg/kg/day. Anomalies of cleft palate were evaluated. The histology results showed cleft palate in the test group. The results of immunohistochemistry showed increased expression of caspase 9 was significant in both test groups. The statistical results indicated that diazepam intake can lead to increase in palatal anomalies and caspase-9 expression.

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Detail Information

Series Title

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Call Number

Farmasains, 1 (4) 2011 : 180184

Publisher

Jakarta : Universitas Muhammadiyah Prof Dr. Hamka., 2011

Collation

5p.

Language

ISBN/ISSN

2086-6968

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

HISTOLOGY
DIAZEPAM
CASPASE 9

Specific Detail Info

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